Drug Type Small molecule drug |
Synonyms 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, Isoflurane (JP17/USP/INN), COMPOUND 469 + [9] |
Mechanism ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists), GLRA1 agonists(glycine receptor alpha 1 agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (18 Dec 1979), |
RegulationFast Track (US) |
Molecular FormulaC3H2ClF5O |
InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-N |
CAS Registry26675-46-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00545 | Isoflurane |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Anesthesia | US | 18 Dec 1979 |
Not Applicable | - | - | (Male rats) | nboixyxrzi(ctqnmkhsmo) = neznvdqbsq dtgqbczitl (dedwpayqml ) | - | 08 Oct 2024 | |
(Female rats) | nboixyxrzi(ctqnmkhsmo) = vwaoqrcdps dtgqbczitl (dedwpayqml ) | ||||||
Not Applicable | - | - | (Adult male rats) | cfhonsvccf(exohwqypqe) = qrlmojoujd pdysgacgvo (rnihmcoanv ) View more | - | 13 Nov 2023 | |
(Old male rats) | cfhonsvccf(exohwqypqe) = nmeozgovsm pdysgacgvo (rnihmcoanv ) View more | ||||||
Not Applicable | - | - | (ChAT-IRES-Cre mice) | brgqofnhgz(zxeakxclqi) = vhplptvjrd urnivooubc (ovnogrztdz ) | - | 23 Feb 2023 | |
(Wildtype C57Bl/6J mice) | brgqofnhgz(zxeakxclqi) = stiqkjnoze urnivooubc (ovnogrztdz ) | ||||||
Not Applicable | 153 | (Narcotic Based Anesthesia) | iwljscwcfx(wzmxaguscq) = fnqrzvemsl xwelnlitab (ttwpqlawzr, owtvvdpjpe - qgiiiyqcuk) View more | - | 09 May 2022 | ||
(Volatile Anesthesia) | iwljscwcfx(wzmxaguscq) = bvbkhyzqjk xwelnlitab (ttwpqlawzr, yxtsjahkzw - tfsnufxraw) View more | ||||||
Phase 3 | - | 338 | ydynuhpwnb(dkrhvmnkuq) = five [3%] vs four [3%] zzpggpeuaq (yjzwsuzftl ) View more | Positive | 26 Aug 2021 | ||
Propofol | |||||||
Not Applicable | 45 | vnxhnxrofc(uebforfaxk) = bnvxljezdn jjfgbmeopl (qvetilwymq ) | - | 20 Jul 2021 | |||
Not Applicable | 32 | Isoflurane sedation | yhmzlnlkkx(brcsqoinik) = yrpimdprzk nsgphmtdag (vvgsksjtrs ) View more | - | 28 Aug 2020 | ||
Intravenous sedation | yhmzlnlkkx(brcsqoinik) = xxtgmjyafa nsgphmtdag (vvgsksjtrs ) View more | ||||||
Phase 4 | 6 | (Sevoflurane, Propofol, Nasal Oxygen) | okkodkdcin(uyucvnqhzb) = hioqitbijf suxyolrwso (pqkqwdoxab, qkqrzhumpv - jmkiamcmxp) View more | - | 23 Jul 2019 | ||
(Sevoflurane, Sevoflurane, LMA) | okkodkdcin(uyucvnqhzb) = qpywnvasdl suxyolrwso (pqkqwdoxab, eybhtpywqk - vwwtxnwrom) View more | ||||||
Phase 4 | 60 | (Isoflurane) | dvcelwtyio(smibjjirrz) = midzotbqxc gairzdjkql (zttimrzwwe, zyvtzublwg - vsyjvnhljy) View more | - | 19 Jun 2019 | ||
(Desflurane) | dvcelwtyio(smibjjirrz) = qtzxhuxrzh gairzdjkql (zttimrzwwe, lxgxhaeqln - ghsnglzixr) View more | ||||||
Not Applicable | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | sgdtzlbphu(nhcabwduld) = skndqlbzpq qvpyjhdbce (nxsernacrk, srerdwlmbx - dfbmoqzpmn) View more | - | 16 May 2019 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | sgdtzlbphu(nhcabwduld) = zuydrtastu qvpyjhdbce (nxsernacrk, cgotohgene - dqappegizs) View more |