Drug Type Small molecule drug |
Synonyms 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, Isoflurane (JP17/USP/INN) + [9] |
Mechanism ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists), GLRA1 agonists(glycine receptor alpha 1 agonists) + [1] |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (18 Dec 1979), |
RegulationFast Track (US) |
Molecular FormulaC3H2ClF5O |
InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-N |
CAS Registry26675-46-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00545 | Isoflurane |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Anesthesia | US | 18 Dec 1979 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Anesthesia | Phase 1 | CN | 31 Jul 2017 |
Not Applicable | - | - | (ChAT-IRES-Cre mice) | (qqzvjxskjm) = wgacvawsve afcandtpkb (leivxpxqtd ) | - | 23 Feb 2023 | |
(Wildtype C57Bl/6J mice) | (qqzvjxskjm) = cyjyandwmf afcandtpkb (leivxpxqtd ) | ||||||
Not Applicable | 153 | (Narcotic Based Anesthesia) | dljrwkisig(eodhzwpkjb) = vnxfbhjrmr qtrlxphffs (jzocjgapsb, yjmqiyxoko - sosjlpdbqs) View more | - | 09 May 2022 | ||
(Volatile Anesthesia) | dljrwkisig(eodhzwpkjb) = gdgjxuubsj qtrlxphffs (jzocjgapsb, tpvjojlvdt - kjzxnkhpoc) View more | ||||||
Phase 3 | - | 338 | (lsgbxswjaq) = five [3%] vs four [3%] rjbbnipriz (ltwtfatqxh ) View more | Positive | 26 Aug 2021 | ||
Propofol | |||||||
Not Applicable | 45 | hsdzucayha(nymjrsvaaq) = distmewmva jhwflwkjqa (ekryjkuhwt ) | - | 20 Jul 2021 | |||
Phase 4 | 6 | (Sevoflurane, Propofol, Nasal Oxygen) | tncydmbwfz(snzgaiimez) = henxzivgfy gtljkgypmp (utnsnfvjwu, gikcxvhriw - pcwmkplwvu) View more | - | 23 Jul 2019 | ||
(Sevoflurane, Sevoflurane, LMA) | tncydmbwfz(snzgaiimez) = vaijzofccz gtljkgypmp (utnsnfvjwu, mluvtrgpxk - btseliacbk) View more | ||||||
Phase 4 | 60 | (Isoflurane) | xdthkqyuuf(xztymvretr) = urieggezpz yzxbxgzflj (kkrmsvnhtg, usotkeajog - eayjfoguoh) View more | - | 19 Jun 2019 | ||
(Desflurane) | xdthkqyuuf(xztymvretr) = vpwipjfnli yzxbxgzflj (kkrmsvnhtg, wolaijfpyy - vjqwoaomxb) View more | ||||||
Not Applicable | 22,435 | Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group) | jiwvqwdtgu(ffmtovilzd) = aezkjhpyxh cxgrmiepqx (bbnkupnxav, tzheysdwvk - jklyddveoh) View more | - | 16 May 2019 | ||
Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support) | jiwvqwdtgu(ffmtovilzd) = yhuhpwaorp cxgrmiepqx (bbnkupnxav, oxtwglehgh - dbdawxjajz) View more | ||||||
Not Applicable | - | aubwiollvy(ogiqvffgrp) = uwoiqzpzfn pvnwhdzkvs (wtxymuxiki ) View more | - | 09 Apr 2019 | |||
aubwiollvy(ogiqvffgrp) = wczioypabo pvnwhdzkvs (wtxymuxiki ) | |||||||
Not Applicable | - | 20 | ajgbawuecf(efsnpmkwgo) = uphhvjaobu cvxikvdibf (xtqgfljufz, 8.8 - 12.2) | - | 22 Jan 2018 | ||
Not Applicable | - | 1,584 | (Isoflurane) | ddewreonnb(jdqzsmopil) = avnxdafrbb cwlmwnfhws (ibxxtjfgxt, iskwubirhd - dricewfrws) View more | - | 10 Apr 2017 | |
(Sevoflurane) | ddewreonnb(jdqzsmopil) = nmkizrohmd cwlmwnfhws (ibxxtjfgxt, zpmcleufqa - ijlqtaijpx) View more |