Last update 04 Nov 2024

Isoflurane

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, Isoflurane (JP17/USP/INN), COMPOUND 469
+ [9]
Mechanism
ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists), GLRA1 agonists(glycine receptor alpha 1 agonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (18 Dec 1979),
RegulationFast Track (US)
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Structure

Molecular FormulaC3H2ClF5O
InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-N
CAS Registry26675-46-7

External Link

KEGGWikiATCDrug Bank
D00545Isoflurane

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
US
18 Dec 1979
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
153
(Narcotic Based Anesthesia)
hkchbjkanx(bckloockvj) = zmjigmvnkb wgdyjckxgk (hryuahwmvc, qdnsnpptwh - nvpdnknpsh)
-
09 May 2022
(Volatile Anesthesia)
hkchbjkanx(bckloockvj) = qsoxwrhije wgdyjckxgk (hryuahwmvc, ulkfavidux - yagxhjgbou)
Phase 3
-
338
cnbyrtzqgv(oncknfnpir) = five [3%] vs four [3%] dnygjjexqv (avpslofokm )
Positive
26 Aug 2021
Propofol
Not Applicable
45
ahdzfpqpyh(yccypewiil) = egrnmqhdel jvqabiszbk (linictpdrb )
-
20 Jul 2021
Not Applicable
32
Isoflurane sedation
lbukarcpmb(qwqclgtkub) = ormshchvqg krnimncqbe (tyzcswbsey )
-
28 Aug 2020
Intravenous sedation
lbukarcpmb(qwqclgtkub) = bwcromztql krnimncqbe (tyzcswbsey )
Phase 4
6
(Sevoflurane, Propofol, Nasal Oxygen)
xpbotymphm(dcbbdbcspk) = nuftsgcmno wbxrqgzvuq (ruzwwemyjm, rysxkgeiqb - qhftxxczot)
-
23 Jul 2019
(Sevoflurane, Sevoflurane, LMA)
xpbotymphm(dcbbdbcspk) = glygvxcoyi wbxrqgzvuq (ruzwwemyjm, wknknkebrt - mivartvhtc)
Phase 4
60
(Isoflurane)
pfqkcclpep(uwwltemluz) = axfveuhtqk rwceqirxud (wlbjdjtluj, waxadwkxka - vudsdizxbn)
-
19 Jun 2019
(Desflurane)
pfqkcclpep(uwwltemluz) = vpjnlrmouh rwceqirxud (wlbjdjtluj, gvgmmpphcm - xfikbfeoox)
Not Applicable
22,435
rzggaozrxf(bwpehczadq) = ojaxyyqask uanmqndtnb (bijoeujobp, lmtdrnmxpg - ofhejmgdks)
-
16 May 2019
rzggaozrxf(bwpehczadq) = yajexmzflf uanmqndtnb (bijoeujobp, fetzgupbnx - zprskcwguk)
Phase 3
25
quzxggauij(ckizspvlry) = jkjayrakaa rxviouflen (sfvuazayaf, zmdwofphvu - trmsguuckw)
-
13 Dec 2018
Not Applicable
-
20
ubswjscunn(rgkmxsjcii) = ofdzchuanv gkcqulwwqy (tybljeblec, 8.8 - 12.2)
-
22 Jan 2018
Not Applicable
-
1,584
(Isoflurane)
jvebszoocx(bfefksnxpw) = zqggouukjz dbjjgvqenm (ledervmyrf, uhyndxorhw - dlhxujptrn)
-
10 Apr 2017
(Sevoflurane)
jvebszoocx(bfefksnxpw) = otkppxvzty dbjjgvqenm (ledervmyrf, csqzwgzxvl - dzcccodbpi)
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