ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists), GLRA1 agonists(glycine receptor alpha 1 agonists)

+ [1]

Therapeutic Areas

Other Diseases

Active Indication

Anesthesia

Inactive Indication-

Originator Organization

Baxter Healthcare Corp.

Active Organization

Baxter Healthcare Corp.

Hebei Yipin Pharmaceutical Co., Ltd.

Inactive Organization

Yichang Humanwell Pharmaceuticals Co., Ltd.

Drug Highest PhaseApproved

First Approval Date

United States (18 Dec 1979),

Anesthesia

RegulationFast Track (United States)

Structure/Sequence

Molecular FormulaC3H2ClF5O

InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-N

CAS Registry26675-46-7

149

Clinical Trials associated with Isoflurane

NCT06252207

/ Not yet recruitingNot ApplicableIIT

Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge: a Cluster Randomized Crossover Trial

The investigators thus propose a comparative effectiveness quality improvement project to evaluate the feasibility of switching from near-exclusive use of isoflurane in adult general surgical patients to Desflurane.

Start Date15 Mar 2025

Sponsor / Collaborator

The Cleveland Clinic Foundation

NCT06624592

/ RecruitingPhase 3IIT

Sevoflurane/Dexmedetomidine Vs. Isoflurane and Their Effects on Pediatric Emergence Delirium

The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.

Start Date20 Dec 2024

Sponsor / Collaborator

Mayo Clinic

IRCT20090415001815N2

/ RecruitingPhase 2/3IIT

Comparison the effect of isoflurane-remifentanyl versus prpofol-remigentanil on bleeding and Surgeon satisfaction during microscopic ear surgery

Start Date01 Nov 2024

Sponsor / Collaborator

Shiraz University of Medical Sciences

100 Clinical Results associated with Isoflurane

100 Translational Medicine associated with Isoflurane

100 Patents (Medical) associated with Isoflurane

16,486

Literatures (Medical) associated with Isoflurane

01 Apr 2025·Journal of Equine Veterinary Science

Evaluation of spectral entropy monitor with different concentrations of isoflurane in Horses

Article

Author: Domínguez, J M ; Ruíz-López, P ; Morgaz, J ; Granados, M M ; Gómez-Villamandos, R J ; Quirós-Carmona, S ; Navarrete-Calvo, R

Spectral entropy and bispectral index (BIS) can differentiate between conscious and unconscious levels in horses. This study aimed to determine whether spectral entropy and BIS parameters can distinguish between different end-tidal isoflurane concentrations (EtIso, %), and whether these parameters change when a nociceptive stimulus is applied. Ten clinically healthy horses were anaesthetized using xylazine, diazepam, ketamine, and isoflurane. The following parameters were monitored: EtIso, response entropy (RE), state entropy (SE), RE-SE difference, BIS, and electromyography (EMG). Three EtIso concentrations were randomly assigned: 0.9 % (EtIso0.9), 1.2 % (EtIso1.2), and 1.5 % (EtIso1.5). Ten minutes after reaching the first EtIso, the parameters were recorded at baseline (Baseline) and for 5 min following the application of an electrically nociceptive stimulus (first two minutes, EarlyP; the last three minutes, LateP). This procedure was repeated three times for each EtIso. A two-way repeated measures ANOVA was performed. The RE, SE, BIS, and EMG parameters exhibited a significant increase upon the application of a painful stimulus. Notably, only the EMG parameter demonstrated significant differences between EtIso0.9 and EtIs1.5 during both EarlyP and LateP phases (EarlyP: EtIso0.9, 72 ± 23 vs EtIso1.5, 48 ± 23, (P = 0.011); LateP: EtIso0.9, 65 ± 27 vs EtIso1.5, 43 ± 23, (P = 0.022)). Currently, these monitors do not appear to be useful for assessing anaesthetic depth in horses under the studied conditions, although they do seem to be useful for detecting induced nociceptive stimuli.

15 Mar 2025·Veterinary Record

Examining the arrhythmogenicity of dobutamine when used in conjunction with isoflurane in horses: A retrospective study at a single university teaching hospital

Article

Author: Ishihara, Toshitsugu ; Reed, Rachel ; Nieves, Emily ; Hofmeister, Erik

AbstractBackgroundDobutamine is used to treat hypotension in isoflurane‐anaesthetised horses but may produce arrhythmias. Halothane is a volatile anaesthetic that was, historically, widely used in horses, but in one study, 56 of 200 halothane‐anaesthetised horses (28%) developed arrhythmias after dobutamine administration. Although isoflurane has largely replaced halothane, it is unknown how isoflurane and dobutamine interact in the development of arrhythmias.MethodsThe medical records of horses undergoing general anaesthesia at the University of Georgia Veterinary Teaching Hospital in 2015 were reviewed retrospectively. Cases were selected if isoflurane was used as the maintenance inhalant anaesthetic agent and dobutamine was administered for the treatment of hypotension. Any instances of arrhythmia occurring following dobutamine administration were recorded.ResultsArrhythmia occurred after dobutamine administration in six out of a total of 148 horses (4.0%).LimitationsThe retrospective nature of this study and the fact that the horses were anaesthetised at a single institution might limit the extent to which the findings can be generalised.ConclusionCompared to halothane, isoflurane has a much lower incidence of arrhythmia when used with dobutamine. However, a larger‐scale study is needed to identify risk factors associated with horses developing an arrhythmia induced by isoflurane in combination with dobutamine.

04 Mar 2025·Journal of Occupational and Environmental Hygiene

A study of worker isoflurane exposure levels in Australian veterinary workplaces

Article

Author: Johnson, Louisa ; Johnstone, Kelly

Isoflurane is commonly used in veterinary clinics to anesthetize patients and has known acute and chronic health effects. Exposure to isoflurane should be kept as low as reasonably achievable, to minimize the risk of potential health impacts on workers. This study aimed to evaluate the effectiveness of recommended hazard controls for the management of isoflurane exposure to veterinary staff performing regular anesthesia procedures in equine and small animal settings. Isoflurane exposures were assessed via personal passive sampling using a gas and vapor monitor. It was found that when commonly recommended controls are utilized, including active scavenging systems, leak testing circuitry before use, using a cuffed endotracheal tube, avoiding chamber or mask inductions, and recovering the patient on pure oxygen before disconnection from anesthetic circuitry, worker exposures were below the lowest international Occupational Exposure Standard (OEL) of 2 ppm, in both an equine and small animal setting, with exposures in the equine clinic results having an estimated arithmetic mean of 0.52 ppm (GSD = 1.52) and exposures in the small animal clinics results having an estimated arithmetic mean of 0.34 ppm (GSD = 2.06). Results indicate that additional hazard controls could reduce exposures further and include limiting the total minutes of exposure to isoflurane, delivering the lowest effective isoflurane % to the patient, minimizing the number of times vaporizers are refilled during a work shift, and ensuring that surgery room ventilation is maximized.

News (Medical) associated with Isoflurane

29 May 2024

·www.prnewswire.com

Sedana Medical completes patient recruitment for its clinical program in the US

STOCKHOLM, May 29, 2024 /PRNewswire/ -- Sedana Medical AB (publ) announces that all 235 randomized patients have been recruited for its INSPiRE-ICU 2 phase III clinical trial in the United States. Earlier this spring, Sedana Medical reported the completion of enrolment to the parallel phase III clinical trial INSPiRE-ICU 1. The company anticipates topline results from both trials in the second half of 2024, with a planned New Drug Application (NDA) submission in the first quarter of 2025. "The completion of INSPiRE-ICU 2 concludes Sedana Medical´s clinical trials in the United States. Running this study together with esteemed clinical investigators from highly ranked academic centers such as Columbia, the Harvard-affiliated medical center Beth Israel Deaconess Medical Center and many others has been very exciting and rewarding. Many investigators from the participating sites have been excited to be part of our pioneering studies. The bedside experience in the studies has generated a lot of interest in using inhaled sedation in US practice, which we hope will be possible soon," said Peter Sackey, Chief Medical Officer of Sedana Medical. Peter Sackey further elaborated: "We now enter into an intense phase of final monitoring, data cleaning and transfer to our statistician team for analysis. In parallel, the long-term outcomes at 3 and 6 months are being collected centrally by the Critical Illness, Brain Dysfunction, and Survivorship team at Vanderbilt Medical Center. With this parallel approach, we expect topline results for the 30-day outcomes in both studies a few months´ apart before the end of this year, and a swift regulatory submission in Q1, 2025." "The inhaled sedative isoflurane, studied in this trial, is a mainstay of general anesthesia during surgery because of its unique and straightforward pharmacokinetic and pharmacodynamic profile, properties that may potentially also benefit ICU patients. We are very excited to complete enrolment in this trial and eagerly await results evaluating its potential use as a sedative for ventilator-dependent adult ICU patients in the US," said Jeremy Beitler, MD, MPH at Columbia University and Senior Lead Investigator for the INSPiRE-ICU 2 study. Johannes Doll, President and CEO of Sedana Medical, stated: "Completing enrolment of our clinical program marks an important milestone on our journey towards making inhaled sedation accessible to intensive care patients in the United States. I would like to sincerely thank all our clinical trial sites, partners, and the Sedana Medical team for this significant achievement. It makes me very proud that we have been able to convene this exceptional group of intensive care teams from some of the most prominent US hospitals. Their advice and support will be invaluable as we work towards launching our inhaled therapy on the US market." INSPiRE-ICU 1 and 2 are two identical randomized phase III trials, aiming to confirm the efficacy and safety for sedation with isoflurane delivered via Sedana Medical's unique medical device Sedaconda ACD. The primary endpoint is the proportion of time spent at adequate depth of sedation, compared with intravenous sedation using propofol. In addition, several important secondary endpoints are being studied, including opioid use, time to wake-up, cognitive recovery and spontaneous breathing. The first patient was included in April 2022, and 31 highly reputed clinics in the United States are involved in the two trials. The design of the US studies is similar to the Sedaconda study (SED001) successfully performed in Europe in 2017–2019, which resulted in market approval in 2021. For additional information, please contact: Johannes Doll, CEO, +46 (0)76 303 66 66 Johan Spetz, CFO, +46 (0)730 36 37 89 [email protected] About Sedana Medical Sedana Medical AB (publ) is a pioneer medtech and pharmaceutical company focused on inhaled sedation to improve the patient's life during and beyond sedation. Through the combined strengths of the medical device Sedaconda ACD and the pharmaceutical Sedaconda (isoflurane), Sedana Medical provides inhaled sedation for mechanically ventilated patients in intensive care. Sedana Medical has direct sales in Benelux, France, Germany, Great Britain, the Nordics, and Spain. In other parts of Europe as well as in Asia, Australia, Canada, and South- and Central America, the company works with external distributors. Sedana Medical was founded in 2005, is listed on Nasdaq Stockholm (SEDANA) and headquartered in Stockholm, Sweden. This information was brought to you by Cision The following files are available for download:

Phase 3

25 Apr 2024

·www.prnewswire.com

Sedana Medical completes patient recruitment for INSPiRE-ICU 1 clinical trial in the US

STOCKHOLM, April 25, 2024 /PRNewswire/ -- Sedana Medical AB (publ) announces that all 235 randomized patients have been recruited for its INSPiRE-ICU 1 phase III clinical trial in the United States. Concurrently, the identical INSPiRE-ICU 2 trial is nearing completion, with 23 of 235 randomized patients remaining. The company anticipates topline results from both trials in the second half of 2024, with a planned New Drug Application (NDA) submission in the first quarter of 2025. "The completion of the INSPiRE-ICU 1 study marks a true milestone for Sedana Medical. Launching the randomized controlled multicenter studies across the large and diverse US healthcare landscape, in mixed surgical and medical ICUs with a different staffing and workflow compared to Europe, has been exciting. There is a lot of enthusiasm and interest in using inhaled sedation in US practice, which we hope will be possible soon", said Peter Sackey, Chief Medical Officer of Sedana Medical. Peter Sackey further elaborated: "Once the 30-day follow-up of all patients is complete, we will enter into an intense phase of final monitoring, data cleaning and transfer to our statistician team for analysis. In parallel, the long-term outcomes at 3 and 6 months will be collected centrally by the Critical Illness, Brain Dysfunction, and Survivorship team at Vanderbilt Medical Center. With this parallel approach, we expect topline results in the autumn of this year and a swift regulatory submission in Q1, 2025". "Working on these trials from initial design to implementation and completion has been very rewarding and has brought together many experienced clinical researchers in critical care across the US. We, and the clinicians at the bedside, are eager to see inhaled sedation available also in the US", said Christopher Hughes, Professor of Anesthesiology at Vanderbilt University Medical Center and Senior Lead Investigator for the INSPiRE-ICU 1 study. Johannes Doll, President and CEO of Sedana Medical, expressed gratitude, stating: "I would like to sincerely thank all our clinical trial sites, partners, and the Sedana Medical team for this significant achievement. It makes me very proud that we have been able to convene this exceptional group of intensive care teams from some of the most prominent US hospitals. Their advice and support will be invaluable as we work towards making the benefits of inhaled sedation accessible to patients in the United States." INSPiRE-ICU 1 and 2 are two identical randomized phase III trials, aiming to confirm the efficacy and safety for sedation with isoflurane delivered via Sedana Medical's unique medical device Sedaconda ACD. The primary endpoint is the proportion of time spent at adequate depth of sedation, compared with intravenous sedation using propofol. In addition, several important secondary endpoints are being studied, including opioid use, time to wake-up, cognitive recovery and spontaneous breathing. The first patient was included in April 2022, and 31 highly reputed clinics in the United States are involved in the two trials. The design of the US studies is similar to the Sedaconda study (SED001) successfully performed in Europe in 2017–2019, which resulted in market approval in 2021. For additional information, please contact: Johannes Doll, CEO, +46 (0)76 303 66 66 Johan Spetz, CFO, +46 (0)730 36 37 89 [email protected] About Sedana Medical Sedana Medical AB (publ) is a pioneer medtech and pharmaceutical company focused on inhaled sedation to improve the patient's life during and beyond sedation. Through the combined strengths of the medical device Sedaconda ACD and the pharmaceutical Sedaconda (isoflurane), Sedana Medical provides inhaled sedation for mechanically ventilated patients in intensive care. Sedana Medical has direct sales in Benelux, France, Germany, Great Britain, the Nordics, and Spain. In other parts of Europe as well as in Asia, Australia, Canada, and South- and Central America, the company works with external distributors. Sedana Medical was founded in 2005, is listed on Nasdaq Stockholm (SEDANA) and headquartered in Stockholm, Sweden. This information was brought to you by Cision The following files are available for download:

Phase 3NDA

02 Apr 2024

·www.prnewswire.com

Mars Veterinary Health pilots industry-leading anaesthetic gas capture technology to reduce carbon emissions

World's leading provider of veterinary care will be first to introduce innovative in-clinic solution to support sustainability goals BIRMINGHAM, England, April 3, 2024 /PRNewswire/ -- Mars Veterinary Health, through its UK veterinary group Linnaeus and in partnership with Waltham Petcare Science Institute, today announced a first-of-its-kind partnership with SageTech Veterinary to pilot an innovative anaesthetic gas capture solution to help prevent harmful greenhouse gases from entering the atmosphere. During a typical anaesthetic procedure, less than five percent of the volatile anaesthetic agent delivered to a patient is absorbed and metabolised, leaving approximately 95 percent it to be exhaled. Continue Reading Mars Veterinary Health pilots industry-leading anaesthetic gas capture technology to reduce carbon emissions SageTech's trusted gas-capture technology—which is currently used in human healthcare—works by capturing the waste anaesthetic agent breathed out during an operation by safely adsorbing it into a specially developed reusable capture canister. These waste anaesthetic agents can then be extracted from the filter, avoiding current routes for disposal of volatile anaesthetic agents of incineration or release into the atmosphere. "As a leading provider of veterinary care, we have a responsibility to take climate action at scale and lead the way toward more sustainable practices," said Ellie West, RCVS and EBVS® European Specialist in Veterinary Anaesthesia and Analgesia, and Linnaeus Environmental Sustainability Lead. "Our innovative collaboration should help us take a significant step forward in our sustainability journey, aimed at contributing to a better future for the planet—and the people and pets who depend on it." A veterinary-industry first, Mars Veterinary Health's one-year pilot will start with 10 Linnaeus primary care and referral veterinary practices in the UK with the aim of reducing anaesthesia-related carbon emissions resulting from release or disposal of these agents and determining the efficiency of capture in its clinics, ultimately supporting its goal of reducing climate-change impacts. Mars Veterinary Health aims to use these learnings to explore the potential application of this technology across other parts of its business in the years to come. "At SageTech Veterinary, we are excited to share our developed technology and work alongside Mars Veterinary Health to significantly reduce the carbon footprint associated with the direct release of waste volatile anaesthetic agents to the environment," said Iain Menneer, CEO of SageTech Medical. "It has been wonderful to work with the Linnaeus and Waltham teams, and we are confident this pilot project will demonstrate to the veterinary profession how such collaborations can be a collective force for good." This industry-first pilot in sustainable veterinary care is consistent with Mars, Incorporated's Net Zero Roadmap, a detailed action plan for achieving net zero greenhouse gas emissions by 2050, as well as details on the company's progress and history of working on climate action. Details about Mars, Incorporated's wider sustainability—including climate—work can be found in its Sustainable in a Generation Scorecard. About Mars Veterinary Health Mars Veterinary Health is a global division of Mars Petcare dedicated to delivering high-quality pet healthcare to further its collective Purpose: A BETTER WORLD FOR PETS™. Mars Veterinary Health's 70,000 Associates across 3,000 global veterinary clinics put pets, people, and the planet first. The Mars Veterinary Health family includes Associates at AniCura, Banfield, BluePearl, Creature Comforts, Gentle Oak, Hillside, Linnaeus, Mount Pleasant, Tai Wai, VCA, VES, and VSH who demonstrate compassion and expertise while enabling 35 million pet visits each year. Learn more at marsveterinary.com. About Linnaeus Part of Mars Veterinary Health, Linnaeus is a highly respected community of more than 50 primary care and 17 referral veterinary practices based in the UK. Linnaeus employs over 6,000 pet-loving Associates with some of the country's finest vet and nursing teams who together are committed to excellence and delivering high-quality care to patients. Learn more at linnaeusgroup.co.uk. About Mars Science & Diagnostics Mars Science & Diagnostics is a division of Mars Petcare, a diverse business dedicated to one purpose: A BETTER WORLD FOR PETS™. Science & Diagnostics brings together the power of leading pet health science with expertise across diagnostics, data, and technology to improve outcomes in pet health. Antech, our global veterinary diagnostics business, spans in-house diagnostic laboratory instruments and consumables, including rapid assay diagnostic products and digital cytology services; local and cloud-based data services; practice information management software; reference laboratories; veterinary imaging and technology; education; and telemedicine with board-certified specialist support services. Our at-home diagnostics offering includes Wisdom Panel, the world's most accurate pet DNA test. For 60 years, our Waltham Petcare Science Institute has been advancing science to better understand pet health. About SageTech Veterinary The manufacture of virgin anaesthetic agents and their release as waste volatile gases is highly damaging to the environment and contributes significantly to the total carbon footprint of healthcare. SageTech Veterinary is part of SageTech Medical, a medical device and pharmaceutical company focused on the research, design, manufacture, and distribution of technologies for the capture and recycling of waste volatile anaesthetic agents in human and animal healthcare. Their unique circular economy solution safely captures volatile anaesthetic agents (sevoflurane, isoflurane, desflurane) through actively controlled adsorption onto a reusable capture canister. Learn more at sagetechveterinary.com. Photo - SOURCE Mars PetCare

100 Deals associated with Isoflurane

External Link

KEGG	Wiki	ATC	Drug Bank
D00545	Isoflurane	N01AB06	DB00753

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Anesthesia	United States	Baxter Healthcare Corp.	18 Dec 1979

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Anesthesia	Preclinical	China	Yichang Humanwell Pharmaceuticals Co., Ltd.	24 May 2016

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


APAO2023	Not Applicable	-	-	Isoflurane (ChAT-IRES-Cre mice)	(sgxkafdynj) = qbsaokkauh lpsumtwnao (vggefufdyt )	-	23 Feb 2023
				Isoflurane (Wildtype C57Bl/6J mice)	(sgxkafdynj) = bnexoymbta lpsumtwnao (vggefufdyt )
NCT03882788 (NDO, CTgov)	Not Applicable	Heart Defects, Congenital \| Maternal anesthesia and analgesia affecting fetus or newborn \| Neurodevelopmental Disorders	153	Fentanyl (high dose) (Narcotic Based Anesthesia)	emhqzykddy(vqjumbmqap) = hzqrahhnts zsegcyfcpw (kkszquxedh, oviclldneu - apsgiapsee) View more	-	09 May 2022
				Fentanyl (low dose)+Isoflurane (Volatile Anesthesia)	emhqzykddy(vqjumbmqap) = ogdybsyvqd zsegcyfcpw (kkszquxedh, qbismcxpdo - qbeueqigkn) View more
EUCTR2016-004551-67-SI (Pubmed \| Lancet Respir Med)	Phase 3	-	338	Isoflurane via the Sedaconda anaesthetic conserving device	(tlmawywbxn) = five [3%] vs four [3%] fjlxkayckt (vcxffkypfz ) View more	Positive	26 Aug 2021
				Propofol
NCT05830864 (Pubmed \| Neurocrit Care)	Not Applicable	Status Epilepticus	45	Isoflurane	yavpqsyjdf(hqhqwgxbbz) = xlzaexzwtl eysbfwqney (ytzckfsmuv )	-	20 Jul 2021
NCT02111447 (CTgov)	Phase 4	Emergence Delirium	6	Propofol (Sevoflurane, Propofol, Nasal Oxygen)	ybfuddkith(lgfxgpsaoa) = pavdtvollt gujqtfgqse (usemqexqko, hhrpidwscp - ambfdmjzql) View more	-	23 Jul 2019
				Sevoflurane (Sevoflurane, Sevoflurane, LMA)	ybfuddkith(lgfxgpsaoa) = iuzvywuuye gujqtfgqse (usemqexqko, kmyrdvtcni - koekmfaxad) View more
NCT02925611 (CTgov)	Phase 4	Emergence Delirium	60	Isoflurane (Isoflurane)	hywrpjpqxt(tsqdpuxpmz) = sriqkxrihe ftlrttmbbq (bmvxugmkzl, fwynoywlfr - drsrkuxocr) View more	-	19 Jun 2019
				DESFLURANE (Desflurane)	hywrpjpqxt(tsqdpuxpmz) = umjxtfamkp ftlrttmbbq (bmvxugmkzl, ptaxroeyiw - moufryigpd) View more
NCT02726620 (CTgov)	Not Applicable	Hypotension	22,435	Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group)	rtuntrjyte(jjwehgeynb) = uasyjtcbfs xcnrckekmk (pjrxhwkvgm, bjpxhvipbf - qbpymwrgzo) View more	-	16 May 2019
				Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support)	rtuntrjyte(jjwehgeynb) = fltcwcgavt xcnrckekmk (pjrxhwkvgm, wlocyaueqp - cvjlhuedcd) View more
AAN2019	Not Applicable	Neurotoxicity Syndromes	-	Isoflurane	gqedwlaqrv(ijcxccacum) = mcxogbhnwz holpcnsbad (tecovpnjrk ) View more	-	09 Apr 2019
				Isoflurane + Caffeine	gqedwlaqrv(ijcxccacum) = anszmdebul holpcnsbad (tecovpnjrk )
NCT01819012 (Pubmed \| J Korean Med Sci)	Not Applicable	-	20	Isoflurane	lmmoxkonrq(ttwaegvfmu) = sgoyldxyae jjcesugxbs (ofbrcortvd, 8.8 - 12.2)	-	22 Jan 2018
NCT01379664 (CTgov)	Not Applicable	-	1,584	Isoflurane (Isoflurane)	(bucgiugteg) = cnsztegzwg ewjvuqscuj (uhehqmwfva, ikcccicwyo - uobkkbxatq) View more	-	10 Apr 2017
				Sevoflurane (Sevoflurane)	(bucgiugteg) = nyiiswfqvg ewjvuqscuj (uhehqmwfva, yaalnuiluw - fafzwtyxcc) View more

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