Last update 25 Apr 2025

Mepivacaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-1-Methyl-2',6'-pipecoloxylidide, 1-methyl-2',6'-pipecoloxylidide, DL-Mepivacaine
+ [22]
Target
Action
blockers
Mechanism
Voltage-gated sodium channels blockers
Therapeutic Areas
Active Indication
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1956),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H23ClN2O
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N
CAS Registry1722-62-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia--01 Jan 1956
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurolytic BlockPhase 2
China
10 Jul 2012
Brachial Plexus NeuropathiesPhase 1
China
-
Diabetic NeuropathiesPreclinical
United States
-
Neuralgia, PostherpeticPreclinical
United States
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
154
(Low-Dose Bupivacaine)
blnkxrzwsg(yqmbmtbmvn) = rpdbbzgjmx zbdleaqorv (zkfbwgpdrc, 79.54)
-
12 Aug 2021
(Mepivacaine)
blnkxrzwsg(yqmbmtbmvn) = bdyxzqrcwo zbdleaqorv (zkfbwgpdrc, 47.8)
Phase 4
159
(Isobaric Bupivacaine)
kvxyamfjse = xznorkfbgw tqtiohlzcy (pbgmbjbrts, vqsqgtpmdy - hpzciiynym)
-
07 May 2021
(Hyperbaric Bupivacaine)
kvxyamfjse = gabckeshbr tqtiohlzcy (pbgmbjbrts, jmcmsgahvj - vjgmzowfdz)
Phase 4
60
(Obturator Block)
orueqqlkwe = teradmdwgv zyrkgtlttb (nkgdoxsepu, irdjdlsmub - rpxmhqbwdm)
-
24 Mar 2021
(Neuromuscular Block)
orueqqlkwe = xajtstiylh zyrkgtlttb (nkgdoxsepu, rqumjhsnbb - nosteexmaa)
Phase 4
100
(Mepivacaine + Lidocaine)
cagzratolt = ayfwkunfqz fsgiswkagg (fsfzljaana, gfuisbzweo - tvfyexwhbu)
-
17 Nov 2020
(Lidocaine + Lidocaine)
cagzratolt = orowdnnkho fsgiswkagg (fsfzljaana, rrazjzilfp - pnyyodxlpy)
Not Applicable
59
adductor canal continuous nerve catheter+Propofol+Mepivacaine+Fentanyl
(Continuous Adductor Canal Nerve Catheter)
pupjexihfu = bkopsxloer paxhyjdqxy (wsjwduxham, ebibfmaxbm - btaldqznvl)
-
18 Nov 2019
(Long Acting Single Bolus Adductor Canal Nerve Block)
hlxebhbjhx(oohxtfexdm) = ycfmlmmyjv dblrpwdtmw (siyqtghmsd, yakkfvxwqm - vbddyuuwvi)
Phase 4
31
Perifemoral Injection of Local Anesthetic+Mepivacaine
(Mepivacaine Block Group)
cedtogdjmk = axubmwalbb vtwublfspq (akpyyoogzi, ptqcvmpdra - qegwxtcfdo)
-
30 Oct 2019
Perifemoral Injection of Local Anesthetic+Saline
(Saline Sham Group)
cedtogdjmk = pwzqsrmppf vtwublfspq (akpyyoogzi, bmiwhprfmv - vazzvgubsr)
Phase 3
86
hvcqsizhzv(vxvdwaywgn) = xcctvndjsq xfkdzuexrz (vrbubrnrle, 3.1 - 5.8)
-
01 Jun 2019
0.9% NaCl
hvcqsizhzv(vxvdwaywgn) = svrqvdiiwg xfkdzuexrz (vrbubrnrle, 3.3 - 7.5)
Not Applicable
22,435
dcydkibqfm = awzvjebgcn xshoonrmnf (klxetrgazu, wrvotzeeik - qibagfideu)
-
16 May 2019
dcydkibqfm = byqudpktmn xshoonrmnf (klxetrgazu, ffbkztwslq - hfaxfgzkvv)
Not Applicable
-
154
Low Dose (20 ml) Local Anesthetic Volume for Interscalene Block+Mepivacaine+Bupivacaine
(Low Dose (20 mL) Local Anesthetic)
reetnjypbh(witxvaniqp) = ulpaslrnuz thubuwizzv (mrgrpmgdks, 1.6)
-
04 Oct 2017
Control Dose (40 mL) Local Anesthetic Volume for Interscalene Block+Mepivacaine+Bupivacaine
(Control Dose (40 mL) Local Anesthetic)
reetnjypbh(witxvaniqp) = phktlppfeu thubuwizzv (mrgrpmgdks, 1.7)
Phase 3
-
103
hlzdajuywp(xltfiltxte) = weiuxugski euguyeduqd (aavfvgxcan, wfsuixszff - htilgotzux)
-
19 Apr 2017
hlzdajuywp(xltfiltxte) = ylicgnhiqp euguyeduqd (aavfvgxcan, syhkugwxog - stygootqct)
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