Comparative evaluation of the efficacy of two anesthetic gels Lidocaine 20% and Benzocaine 20% in reducing pain during posterior maxillary infiltration in children aged 7-12 years

Start Date22 Sep 2024

Sponsor / Collaborator

Islamic Azad University

NCT06569537 / Not yet recruitingPhase 4IIT

Comparison of Compounded Topical Anesthetics for Pain Relief of Intense Pulsed Light, Pulse Dye Laser, and Microneedling Treatments

The primary objective for this pilot study is to evaluate the efficacy of the compounded topical anesthetic Benzocaine 20%/ Lidocaine 8%/Tetracaine 4% (BLT) compared to 4% Lidocaine topical in providing relief of pain during IPL, PDL, and microneedling procedures.

Start Date01 Sep 2024

Sponsor / Collaborator

Dartmouth-Hitchcock Medical Center

CTRI/2024/04/065909 / Not yet recruitingPhase 4IIT

Comparative Evaluation of Effectiveness of Benzocaine Gel & Ice for Pain Management in Children During Local Anaesthetic Administration By CCLD, A Randomised Clinical Trial - NIL

Start Date06 May 2024

Sponsor / Collaborator-

100 Clinical Results associated with Ethyl Aminobenzoate

100 Translational Medicine associated with Ethyl Aminobenzoate

100 Patents (Medical) associated with Ethyl Aminobenzoate

1,296

Literatures (Medical) associated with Ethyl Aminobenzoate

01 Dec 2024·JOURNAL OF HAZARDOUS MATERIALS

Characteristics and functional bacteria of an efficient benzocaine-mineralizing bacterial consortium

Article

Author: Wu, Xiangwei ; Yang, Chen ; Zhang, Xiaohan ; Huang, Junwei

The extensive use of pharmaceutical and personal care products (PPCPs) has led to widespread residual pollution, which increases the risk of the development of drug resistance in pathogenic microorganisms. Benzocaine is a PPCP that is widely used medical anesthesia and in sunscreen. Microorganisms are essential for the degradation of residual PPCPs. However, no studies have reported the microbial degradation of benzocaine. In this study, through continuous enrichment of the initial consortium HJ1, the highly efficient benzocaine-degrading consortium HJ7 was obtained, HJ7 exhibited a degradation rate that was 1.92 times greater than that of HJ1. Methyl 4-aminobenzoate and 4-aminobenzoic acid were identified as major intermediate products during benzocaine biodegradation by consortium HJ1 or HJ7. Methylobacillus (57.8 % ± 0.9 %) and Pseudomonas (22.1 % ± 0.7 %), which are thought to harbor essential species for benzocaine degradation, were significantly enriched in consortium HJ7. Two benzocaine-degrading strains, Pseudomonas sp. A8 and Microbacterium sp. A741, and one methyl 4-aminobenzoate-degrading strain, Achromobacter sp. A5, were isolated from consortium HJ7, and they synergistically mineralized benzocaine. These findings not only provide new insights into the biotransformation of benzocaine but also provide strain resources for the bioremediation of residual benzocaine in the environment.

18 Oct 2024·APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Seasonal dynamics of bacterial composition and functions in biological treatment of coking wastewater.

Article

Author: Lin, Yuexia ; Xie, Junting ; Wei, Chaohai ; Xu, Xingyuan ; Guo, Ziyu ; Tan, Zhijie ; Preis, Sergei ; Dai, Jiangpeng ; Zhu, Shuang ; Chen, Wenli ; Sheng, Binbin

Seasonal dynamics of bacterial composition and functions were demonstrated for the biological fluidized-bed bioreactors combined in the anoxic/aerobic1/aerobic2 (AOO) coking wastewater (CWW) treatment sequences. The bacterial composition and functions in the CWW activated sludge samples were revealed by 16S rRNA genes amplicon sequencing. Thiobacillus, Cloacibacterium, Alkaliphilus and Pseudomonas were determined as core genera with seasonal changes. Mutable microbial community composition fluctuated in different seasons in same bioreactor. Distributions of predicted KEGG pathways along four seasons consistently demonstrated enrichment in biodegradation of carbon- and nitrogen-containing compounds. The major contaminants were removed from CWW by biochemical pathway of xenobiotics biodegradation and metabolism. This Level 2 pathway mainly owned the Level 3 pathways of benzoate degradation, drug metabolism-other enzymes, drug metabolism-cytochrome P450, metabolism of xenobiotics by cytochrome P450, and aminobenzoate degradation. The RDA results showed that dissolved oxygen with seasonal fluctuation was the main parameter shaping the microbial community. The observed dynamics within the microbial community composition, coupled with the maintained stability of CWW treatment efficiencies and a consistent profile of microbial functional pathways, underscore the presence of functional redundancy in the AOO bioreactors. The study underscored stable and effective operational performances of bioreactors in the AOO sequences, contributing the knowledge of microbiological basics to the advancement of CWW biological treatment. KEY POINTS: • Seasonal fluctuations of bacterial composition described for the AOO system. • Seasonal distributions of metabolic functions focused on carbon and nitrogen removal. • Functional redundancy was revealed in the AOO microbial community.

25 Sep 2024·ACS Applied Materials & Interfaces

Enhanced Performance and Stability of Perovskite Solar Cells Through Surface Modification with Benzocaine Hydrochloride

Article

Author: Luo, Shizi ; Troshin, Pavel A. ; Xu, Xueqing ; Aldoshin, Sergey M. ; Xue, Qifan ; Ramachandran, Bala R. ; Bi, Zhuoneng ; Bolshakova, Valeria S. ; Gutsev, Gennady L. ; Chen, Zukang ; Slesarenko, Nikita A. ; Chen, Xiaoli ; Zheng, Yupeng ; Emelianov, Nikita A. ; Cao, Shuguang ; Ozerova, Victoria V. ; Gutsev, Lavrenty G. ; Hsu, Hsien-Yi

Current development of inverted p-i-n perovskite solar cells (PSCs), with nickel oxide as the hole transport layer, is progressing toward lower net costs, higher efficiencies, and superior stabilities. Unfortunately, the high density of defect-based traps on the surface of perovskite films significantly limits the photoelectric conversion efficiency and operational stability of perovskite solar cells. Finding cost-effective interface modifiers is crucial for the further commercial development of p-i-n PSCs. In the present work, we report a passivation strategy using a multifunctional molecule, benzocaine hydrochloride (BHC), which is shown to reduce defect density and enhance the photovoltaic performance and stability of the resultant p-i-n PSCs. It has been revealed that BHC strongly interacts with perovskite precursor components and triggers the evolution of the perovskite absorber film morphology and enables improved surface energy level alignment, thus promoting charge carrier transport and extraction. These properties are beneficial for improving open-circuit voltage (V_OC) and fill factor (FF). Our results show that the photoelectric conversion efficiency (PCE) of p-i-n PSCs with nickel oxide as the hole transport layer increased from an initial 20.0% to 22.1% after being passivated with BHC, and these passivated devices also exhibited improved stability. DFT calculations reveal the unusual ability of the BHC passivant to improve band alignment while also preventing the accumulation of holes at the interface. In this work, the advantages of BHC passivation are demonstrated by linking theoretical calculations with optical and electrical characterizations.

News (Medical) associated with Ethyl Aminobenzoate

22 Dec 2023

·www.biospace.com

Insight Pharmaceuticals Issues Voluntary Nationwide Recall of Americaine® 20% Benzocaine Topical Anesthetic Spray Due to the Presence of Benzene

TARRYTOWN, N.Y., Dec. 22, 2023 (GLOBE NEWSWIRE) -- Insight Pharmaceuticals, a Prestige Consumer Healthcare Inc. company (“Insight”), is voluntarily recalling one lot of Americaine® 20% Benzocaine Topical Anesthetic Spray to the consumer level. While benzene is not an ingredient in any Americaine® 20% Benzocaine Topical Anesthetic Spray products, a recent review by our manufacturer and their third-party lab found that a sample from one lot of the product showed a low level of benzene came from the propellant that sprays the product out of the can. Importantly, no other lots of Americaine® 20% Benzocaine Topical Anesthetic Spray (either before or after this batch code) are in the scope of this recall and may continue to be used by consumers safely and as intended. Risk Statement: Benzene is classified as a human carcinogen. Exposure to benzene can occur by inhalation, orally, and through the skin and it potentially can result in cancers including leukemia and blood cancer of the bone marrow and blood disorders which can be life threatening. Insight is recalling these products out of an abundance of caution. To date, the Company has not received any serious adverse events related to this recall. Benzene is ubiquitous in the environment. Humans around the world have daily exposures to it indoors and outdoors from multiple sources. Americaine® 20% Benzocaine Topical Anesthetic Spray is packaged in white aerosol cans with Teal caps with Lot codes located on the bottom of the can. Samples of the recalled lot below have been found to contain trace levels of Benzene related to the propellant that sprays the product out of the can. Benzene is not an ingredient in any Americaine products. Product NDC Lot Code Expiration Package Size Americaine® 20% Benzocaine Topical Anesthetic Spray 63736-378-02 1A16420 01/25 2 oz / 57 g The affected Americaine® 20% Benzocaine Topical Anesthetic Spray lot was distributed nationwide in the United States through a limited number of retailers and online. Insight has notified retailers via overnight mail to remove any remaining recalled product from shelves and follow the instructions provided in the Drug Recall Notification. The company will also offer reimbursement for consumers who have purchased Americaine® 20% Benzocaine Topical Anesthetic Spray marked with the lot code in the table above. Consumers can contact Insight Pharmaceuticals via e-mail at medicalaffairs@prestigebrands.com, through its website at , or by phone at (800) 344-7239 on Monday – Friday 8:30-5:30 eastern time to receive a full refund by providing a picture of the bottom of the can of the Americaine® 20% Benzocaine Topical Anesthetic Spray with the affected lot number. Consumers that have product which is being recalled should stop using the product immediately and appropriately discard after taking the picture. Consumers should contact their physician or healthcare provider if they have experienced any problems that may be related to taking or using this anesthetic product. No serious adverse events have been reported to date. Adverse reactions or quality problems experienced with the use of this product may be reported to the FDA's MedWatch Adverse Event Reporting program either online, by regular mail or by fax. Complete and submit the report Online: Regular Mail or Fax: Download form or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178. This recall is being conducted with the knowledge of the U.S. Food and Drug Administration. A photo accompanying this announcement is available at . Investor Relations Contact Phil Terpolilli, CFA, 914-524-6819 irinquiries@prestigebrands.com Americaine® 20% Benzocaine Topical Anesthetic Spray Americaine® 20% Benzocaine Topical Anesthetic Spray

07 Nov 2023

·www.prnewswire.com

Advanced Anesthesia Devices and Ambulatory Surgical Centers Propel Growth in the US Anesthesia Market

DUBLIN, Nov. 7, 2023 /PRNewswire/ -- The "The US Anesthesia Drugs and Devices Market (by segment, Type, Drug Product, & Device Product): Insights and Forecast with Potential Impact of COVID-19 (2022-2027)" report has been added to ResearchAndMarkets.com's offering. The US anesthesia drugs and devices market is poised for significant growth, with a projected value of US$6.83 billion in 2023, experiencing a robust CAGR of 6.78% during the forecasted period. Anesthesia, the use of drugs to alleviate pain during medical procedures, is essential in the healthcare industry and is administered through various means such as injection, inhalation, topical application, and more. Market Segmentation The US anesthesia drugs and devices market is divided into two primary segments: anesthesia drugs and anesthesia devices. Among these segments, anesthesia drugs currently hold the majority share, while the anesthesia devices segment is expected to experience substantial growth due to increased healthcare expenditure in the region. Types and Products In terms of types, the US anesthesia drugs market is categorized into General, Local, and other anesthesia. The General anesthesia drug segment dominates the market, followed by local anesthesia drugs. The development of novel anesthesia drugs through pharmaceutical R&D is expected to create growth opportunities in the "other anesthesia drugs" segment. When considering device products, the market is segmented into advanced, basic, and integrated anesthesia devices. The advanced segment holds the largest share in the market, followed by integrated anesthesia devices. Ongoing advancements in anesthesia monitoring devices and the demand for improved monitoring contribute to the growth of the advanced anesthesia monitoring devices market. The market is further categorized by drug product into Bupivacaine, Ropivacaine, Lidocaine, Chloroprocaine, Prilocaine, Benzocaine, and other local anesthetics. Lidocaine anesthesia drugs have the highest market share, followed by Bupivacaine and Ropivacaine. The market is anticipated to grow due to increasing patient populations and a rise in medical and surgical procedures. Key Drivers and Challenges Driver: Increase in Monitored Anesthesia Use The adoption of Monitored Anesthesia Care (MAC) is on the rise. MAC involves specific anesthesia services for procedures performed under local anesthesia with sedation and analgesia, allowing patients to maintain consciousness. Patients are opting for monitored anesthesia to ensure satisfaction during surgeries, leading to increased usage of anesthesia equipment and drugs. Challenge: Side Effects of Anesthesia While anesthesia is generally administered by anesthesiologists, it can sometimes lead to side effects, including nausea, headache, vomiting, and shivering, among others. General anesthetics can affect the central nervous system, causing drowsiness and coordination problems. These side effects can deter some patients and impact the growth of the anesthesiology market. Trend: Growth of Ambulatory Surgical Centers (ASC) The establishment of ambulatory surgical centers (ASCs) is escalating due to an aging population and the prevalence of chronic diseases. ASCs offer improved reimbursement and a reduced risk of healthcare-associated infections, attracting more patients. This growth in ASCs is driving the demand for anesthesia drugs and devices. COVID-19 Analysis The COVID-19 pandemic led to increased utilization of intensive care unit (ICU) ventilators and anesthesia machines for longer-term ventilation. Anesthesia drugs were used during longer-term ventilation with anesthesia machines. Initially, anesthesia drug demand decreased in 2020 due to postponed or canceled surgeries. However, as elective surgeries resumed, anesthesia drug consumption increased. Key Players The US anesthesia drugs and devices market is competitive and features several major players, including Baxter International Inc., Envision Healthcare Corporation (KKR & Co. Inc.), Becton, Dickinson and Company, TeamHealth (Blackstone), Teleflex Incorporated, Dragerwerk AG & Co. KGaA, B. Braun Avitum AG (Braun), 3M Company, Abbvie Inc., AstraZeneca Plc, Abbott Laboratories, ICU Medical, Inc., SunMed LLC, and General Electric Company. Top Impacting Factors Growth Drivers Rising Geriatric Population Growing Healthcare Expenditure Increase in Monitored Anesthesia Use Increase In Number Of Approval For Anesthesia Drugs Challenges Side Effects of Anesthesia Lack of Skilled Anesthesiologist Trends Escalating Establishment of Ambulatory Surgical Centers (ASC) Technological Enhancement of Anesthesia Devices For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo - SOURCE Research and Markets

27 Jun 2023

·www.prnewswire.com

AMERICAN ACADEMY OF DERMATOLOGY URGES AMERICANS TO USE SUN PROTECTION AHEAD OF JULY 4th WEEKEND

Board-certified dermatologist provides tips to relieve discomfort from sunburns ROSEMONT, Ill., June 27, 2023 /PRNewswire/ -- The July 4th weekend is a time when many Americans will celebrate outdoors at parades, pools and cookouts, but without proper sun protection, they put themselves and their children at risk of getting sunburned, which increases the chances of developing skin cancer. A recent American Academy of Dermatology survey of more than 1,000 U.S. adults revealed that one-third of American parents reported having a child who was sunburned in 2022. Sunburn, which is the result of skin receiving too much exposure from the sun's ultraviolet (UV) rays, can cause long-lasting damage to the skin. "The survey data is troubling because blistering sunburns and childhood sunburns greatly increase your risk of getting skin cancer, including melanoma, the most serious form," said board-certified dermatologist A. Yasmine Kirkorian, MD, FAAD, chief of dermatology at Children's National Hospital in Washington, D.C. "To some extent, I think parents are aware of the need for sun protection, but at the same time are falling short of adequately protecting their children." People can avoid sunburn by seeking shade, remembering that the sun's rays are the strongest between 10 a.m. and 2 p.m., she said. Additionally, people should wear a lightweight and long-sleeved shirt, pants, a wide-brimmed hat, and sunglasses with UV protection, when possible. The third component of sun protection is applying a broad-spectrum, water-resistant sunscreen with an SPF of 30 or higher to all skin not covered by clothing and reapplying every two hours or after swimming or sweating, said Dr. Kirkorian. "I tell parents to make sure that their children are willing to apply sunscreen themselves," said Dr. Kirkorian. "For their faces in particular, it's often best to try a stick sunscreen because it's easier to apply. I also recommend that they tell their children to go inside to rest during the times of the day when the sun is the strongest." If you get a sunburn, it is important to begin treating it as soon as possible, so the best thing to do is get out of the sun and go indoors, she said. Dr. Kirkorian and the AAD recommend the following tips to help relieve discomfort from a sunburn: Take frequent cool baths or showers to help relieve the pain. As soon as you get out of the bathtub or shower, gently pat yourself dry, but leave a little water on your skin. Then, apply a moisturizer to help trap the water in your skin. This can help ease the dryness. Use a moisturizer that contains aloe vera or soy to help soothe sunburned skin. If a particular area feels especially uncomfortable, you may want to apply a hydrocortisone cream that you can buy without a prescription. Do not treat sunburn with "-caine" products (such as benzocaine), as these may irritate the skin or cause an allergic reaction. Consider taking aspirin or ibuprofen to help reduce any swelling, redness and discomfort. Drink extra water. A sunburn draws fluid to the skin's surface and away from the rest of the body. Drinking extra water when you are sunburned helps prevent dehydration. If your skin blisters, allow the blisters to heal. Blistering skin means you have a second-degree sunburn. You should not pop the blisters, as blisters form to help your skin heal and protect you from infection. Take extra care to protect sunburned skin while it heals. Wear clothing that covers your skin when outdoors. Tightly-woven fabrics work best. When you hold the fabric up to a bright light, you shouldn't see any light coming through. "If your skin starts to blister and you feel unwell from the blisters or heat exhaustion, then you should seek care from an emergency room," said Dr. Kirkorian. "Similarly, if the blisters are very large, you'll want to seek medical care. If you have any questions about ways to properly protect yourself and your family from the sun, partner with a board-certified dermatologist." To find a board-certified dermatologist in your area, visit aad.org/findaderm. More Information Practice Safe Sun How to Treat Sunburn AAD B-Roll Library About the AAD Headquartered in Rosemont, Ill., the American Academy of Dermatology, founded in 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 20,800 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical, and cosmetic treatment of the skin, hair, and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, Pinterest and YouTube and @AADskin1 on Instagram. Editor's note: The AAD does not promote or endorse any products or services. This content is intended as editorial content and should not be embedded with any paid, sponsored or advertorial content as it could be perceived as an AAD endorsement. SOURCE American Academy of Dermatology

100 Deals associated with Ethyl Aminobenzoate

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KEGG	Wiki	ATC	Drug Bank
D00552	Ethyl Aminobenzoate	D04AB04 R02AD01 N01BA05	DB01086

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Anesthesia	JP	Agsa Japan Co., Ltd.	11 May 1984

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Recurrent aphthous ulcer	Phase 3	CN	Shanghai Institute of Pharmaceutical Industry	13 Aug 2014
Acute otitis media	Phase 3	US	Arbor Pharmaceuticals, Inc.	01 Dec 2013
Pain	Phase 3	US	Arbor Pharmaceuticals, Inc.	01 Dec 2013
Earache	Phase 2	US	Arbor Pharmaceuticals, Inc.	01 May 2012

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02726620 (CTgov)	Not Applicable	Hypotension	22,435	Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Usual Care Group)	sadtasmyxi(fzejbsuezv) = ldwnkirllu zduhjjdnnj (tiqegvvbjx, lptgawbrrd - vgfowdovwd) View more	-	16 May 2019
				Central neuraxial anesthesia+Glycopyrrolate+dopamine+Hydroxyethyl starch solutions+Epinephrine+desflurane+bupivacaine+Sodium Chloride 0.9%+propofol+atropine+Ephedrine+Isoflurane+Dobutamine+Vasopressin+Isoproterenol+norepinephrine+Prilocaine+Benzocaine+Procaine+Terlipressin+Tetracaine+ropivacaine+Articaine+levobupivacaine+Milrinone+phenylephrine+Sevoflurane+Mepivacaine+lidocaine+Chloroprocaine (Hypotension Decision Support)	sadtasmyxi(fzejbsuezv) = qrerimfrwc zduhjjdnnj (tiqegvvbjx, cndrfuxodq - qiuobszdvu) View more
NCT02379221 (CTgov)	Not Applicable	Anesthesia	49	Topical+epinephrine+benzocaine+lidocaine	bvxevjczke(hqwpnjpkph) = tmgosddlzg heaelsmwuz (tuaqgzkrqo, ainlxetwcl - mgqzwhwchc) View more	-	24 Oct 2018
NCT01925469 (CTgov)	Phase 4	Analgesia	30	Benzocaine (Benzocaine)	pmgvbwtdar(tmduedposa) = reeyqbjive kynxryzpma (qsgdkssfhk, eqlimcuzaw - ldqdpfwzxe) View more	-	28 Apr 2017
				Saline spray (Saline Spray)	pmgvbwtdar(tmduedposa) = vkjlxugwsv kynxryzpma (qsgdkssfhk, jpgmsawlwm - ezpbkesmgr) View more
NCT01925469 (Pubmed \| Reprod Biomed Online)	Phase 4	Pain, Postoperative	30	Benzocaine spray	tedcbrbrzk(dyloawcvmb) = heuzrexhna lewdyuunqz (qvjmckxjyr, -7.4 to 98.8) View more	-	01 Jun 2014
				Saline spray	tedcbrbrzk(dyloawcvmb) = mdxquoflno lewdyuunqz (qvjmckxjyr, 19.8 - 100) View more
NCT00474175 (CTgov)	Phase 4	Toothache	577	placebo+benzocaine (Placebo)	qxxwuiymbx(srwasgeups) = loauiqvbxi cvbmooyqxa (ovxfwiqqqn, cuffeelrud - uwklrnqsor) View more	-	18 Jan 2012
				Benzocaine (Benzocaine 10%)	qxxwuiymbx(srwasgeups) = cxavfotfng cvbmooyqxa (ovxfwiqqqn, dtlhybjdju - hcsizviyzv) View more
Pubmed \| J Am Dent Assoc	Not Applicable	-	-	Refrigerant	pvbhwzzhnw(otbjtkubsl) = hitfbrigkb oeuzkbxakt (opwskxiqds, +/ - 15.3)	-	01 Jan 2009
				Topical Anesthetic Gel	pvbhwzzhnw(otbjtkubsl) = dhegjchelo oeuzkbxakt (opwskxiqds, +/ - 18.0)

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